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Longevity medicine

For the first time, drugs are being developed to extend canine healthspan itself.

Systems touched: Endocrine, cardiovascular, nervous and immune systems.

What this category actually does

This is the newest and least settled category on the site. Loyal's programmes target the growth-hormone/IGF-1 axis and metabolic ageing in senior and large-breed dogs and are moving through the FDA's conditional-approval pathway. The Dog Aging Project's TRIAD trial tests low-dose rapamycin in healthy middle-aged dogs under academic, placebo-controlled conditions. Supplements in this space sit on real ageing biology but carry far weaker evidence than the drug programmes. Nothing here should be started without your veterinarian.

Key benefits

01
Whole-organism, not single-organ
These interventions aim at the ageing process, so benefits are expected across several systems at once.
02
Addresses the size-lifespan tradeoff
Large and giant breeds age fastest, and IGF-1 biology is the leading explanation.
03
Real regulatory and trial scrutiny
The leading candidates are being tested against placebo and reviewed by regulators, rare in pet products.
04
Access to trials
Enrolment in academic studies can bring intensive monitoring at no cost.

5 products in longevity medicine

LOY-002
Loyal
Daily drug candidate aimed at extending healthy lifespan in senior dogs.
Received an FDA milestone for reasonable expectation of effectiveness, a first for a canine longevity drug.
Availability
In FDA conditional-approval pathway
Cost
Not yet on sale
Visit Loyal
LOY-001 / LOY-003
Loyal
Programmes targeting the growth-hormone/IGF-1 axis in large and giant breeds.
Aimed squarely at the size-lifespan tradeoff: big dogs age faster, and IGF-1 is a leading suspect.
Availability
In development
Cost
Not yet on sale
Visit Loyal
TRIAD Rapamycin Trial
Dog Aging Project
Placebo-controlled trial of low-dose rapamycin in healthy middle-aged dogs.
A multi-site, double-masked academic trial, the closest thing to a canine geroscience gold standard.
Availability
Enrolling / trial-dependent
Cost
No cost to enrolled participants
Visit Dog Aging Project
Leap Years
Animal Bioscience
Senior-dog supplement built on NAD+ and senescent-cell science.
Commercialised out of academic ageing-biology work rather than the usual joint-and-coat formulary.
Availability
Shipping
Cost
Subscription
Visit Animal Bioscience
Longevity+ for Dogs
Petlio
Daily longevity blend for adult and senior dogs.
Stacks six actives drawn from human longevity research into one chew.
Availability
Shipping
Cost
From around $27
Visit Petlio